REVIEW: NIOD Copper Amino Isolate Lipid 1% (CAIL) - The Moisturizer
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REVIEW: NIOD Copper Amino Isolate Lipid 1% (CAIL)

Header The Moisturizer - REVIEW: NIOD Copper Amino Isolate Lipid 1% (CAIL)
Are you worried about wrinkles and fine lines? Is your skin sensitive? You have just found the right cosmetic for you. In this review of the NIOD Copper Amino Isolate Lipid 1% (CAIL) you’ll discover everything about it: how to use it in your skincare routines, where to buy it and why I love it!


Hello! Today I want to talk about one of the most iconic NIOD products, the most cutting-edge DECIEM brand. This CAIL is a curious product, since cataloging it is not easy, maybe we could call it a mask, although it’s not similar to other masks I have used. It has a very interesting composition and one that you can surely benefit from. Do you want to know more about this Copper Amino Isolate Lipid 1% from NIOD? Keep reading!


You can find the NIOD Copper Amino Isolate Lipid 1% (CAIL) on DECIEM (recommended) and on Beauty Bay.

As I said at the beginning, NIOD is the brand through which DECIEM develops and markets its most iconic products with the most advanced technology. In fact, NIOD stands for Non-Invasive Options in Dermal Science. On previous occasions I have told you about other products of the brand, such as the Copper Amino Isolate Serum (CAIS), Superoxide Dismutase Saccharide Mist (SDSM2) or Non-Acid Acid Precursor 15% (NAAP). Today I want you to continue sharing more about the brand’s products and I am going to tell you about one of its best-known products that often sells out because there is a lot of demand: Copper Amino Isolate Lipid 1% (CAIL).

As a curiosity, I think it is interesting to mention that a few months ago DECIEM announced several changes in the company’s product lines. The main idea is to focus on NIOD and The Ordinary and leave out some of the other brands in the group, such as Hylamide and The Chemistry Brand. Personally, I think there were some really good products among the disappearing brands and I think it’s a pity not to be able to get them, so I’ll keep an eye on how it all evolves, hopefully we’ll see some of those products relaunched in The Ordinary or NIOD.

As usually happens with NIOD products, you receive it in a black cardboard box with a very studied aesthetic, something to which the brand has accustomed us. Inside, we find that the product comes in a light gray metal tube. If you are like me and want to extract every last drop of product, I recommend using a key like this one so that nothing remains in its nooks and crannies. This container may not be the most comfortable option, since it is not easy to extract the right amount of product, but in the end you get used to using it.

But what does this CAIL contain? Is it a good fit for your skincare routines? I’m certain it is, since it has very interesting actives within its ingredients list. First of all, we see that it is developed on a squalane base, this makes its texture oily, but if you have oily skin like me, don’t panic, if you use the right amount you don’t have to see an increase in your sebum levels . One of the most fascinating ingredients that it incorporates are copper peptides (GHK-Cu), which I told you about in more detail in my guide on peptides and which have antioxidant and anti-inflammatory properties, all while promoting collagen and elastin production. Without a doubt, this is one of my favorite actives and finding it in this mask is fantastic. In addition to this, we find other ingredients (such as zizanoic vetiver and its patented dihydrodiisoeugenol complex), which help maintain the firmness of the skin, preventing the loss of facial fat that serves as its support. As you can see, the formula is quite promising and, generally speaking, if you want to prevent the signs of aging and the appearance of wrinkles and fine lines, it can be very useful for you.

And now that you know a little better the composition of this CAIL by NIOD, you are surely wondering what its texture is like. When we extract it from the container we see that it does not have a prominent odor and that it has a particular blue color (characteristic of copper peptides), something that you may know if you have tried NIOD CAIS or The Ordinary Multi-Peptide + Copper Peptides 1%. Its texture is oily, since as I mentioned before, it is developed on a squalane base, and it spreads very well on the skin, although if I use a lot of it I have observed that my skin gets a little oilier than usual. However, since it is a product that we must apply in our night routine, you should not worry about that feeling, since when you sleep you will not appreciate it.

When applying it, we must take a small amount, equivalent to a pea, since you won’t need much to spread it correctly all over the face. You will probably have to experiment until you find the perfect amount for you, but remember that you do not need a lot of product. As I said before, you should apply it in your night routine, specifically in the last step after the moisturizer. I try to let some time pass between doing my routine and going to sleep, this way I give my skin a while to absorb all the product and prevent it from getting on the sheets.

One thing to keep in mind is that copper peptides tend to degrade when used with certain active ingredients, especially exfoliating acids or vitamin C, so I recommend not using them together to get the best possible results with your beauty routine.

And does this NIOD CAIL provide good results? Undoubtedly. First of all, I have observed that my skin stays better hydrated, since that squalane base helps me avoid dehydration. It is important to mention that although I have oily skin, I have not seen an increase in oil levels. I have also seen a reduction of fine lines on the forehead, although it must be taken into account that this is because my beauty routines are generally aimed at minimizing (and preventing) those wrinkles through the use of other active ingredients such as retinoids.

Would I use this mask again? Of course. So far it is in my top 3 of the best products of the brand (along with the CAIS and the SDSM2). I really like the sensations when using it and I am satisfied with the results I have achieved from using it, so I will continue using it.



This product should be the last step in your night routine. After cleansing and moisturizing, take a small amount of product (the equivalent of a pea) and spread it well, massaging gently into the face to ensure it is properly absorbed. Then you just have to let it act.

This graphic aims to help you understand in which part of your skincare routine you should use each product.
You don’t need to do all the steps from this routine (but you should always cleanse, moisturize and use sunscreen).
Remember it’s key to do a patch test every time you consider adding new products to your skincare routine.


Squalane, Caprylic/Capric Triglyceride, Glycerin, Aqua (Water), Hydrogenated Starch Hydrolysate, Sucrose Laurate, Propanediol, Sucrose Stearate, Copper Tripeptide-1 Palmitamide, Glycolipids, Hydroxymethoxyphenyl Propylmethylmethoxybenzofuran, Vetiveria Zizanoides Root Extract, Aphanizomenon Flos-aquae Extract, Hydroxymethoxyphenyl Decanone, Bisabolol, Biosaccharide Gum-1, Maltodextrin, Potassium Sorbate, Sodium Benzoate, Chlorphenesin, Phenoxyethanol.

You can find the NIOD Copper Amino Isolate Lipid 1% (CAIL) on DECIEM (recommended) and on Beauty Bay.


Have you tried this NIOD Copper Amino Isolate Lipid? Did you know how you can benefit from copper peptides? Write me a comment if you dare to try it!


If you liked this article and want to continue learning how to take better care of your skin, I recommend you take a look at these other posts:

Do you want to learn to take better care of your skin? You can see an index of all my informative posts here

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The Moisturizer

I’m Nacho and I’m passionate about skincare. I really enjoy learning and sharing my knowledge about skincare and I read scientific papers so you don’t have to. I want to break stereotypes because I believe skincare has no gender: skin is skin.  

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